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Proceedings Paper

OCT monitoring of pathophysiological processes
Author(s): Natalia D. Gladkova; Natalia M. Shakhova; Andrei Shakhov; Galina P. Petrova; Elena Zagainova; Ludmila Snopova; Irina N. Kuznetzova; Yuri Chumakov; Felix I. Feldchtein; Valentin M. Gelikonov; Grigory V. Gelikonov; Vladislav A. Kamensky; Roman V. Kuranov; Alexander M. Sergeev
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Paper Abstract

Based on results of clinical examination of about 200 patients we discuss capabilities of the optical coherence tomography (OCT) in monitoring and diagnosing of various pathophysiological processes. Performed in several clinical areas including dermatology, urology, laryngology, gynecology, and dentistry, our study shows the existence of common optical features in manifestation of a pathophysiological process in different organs. In this paper we focus at such universal tomographic optical signs for processes of inflammation, necrosis and tumor growth. We also present data on dynamical OCT monitoring of evolution of pathophysiological processes, both at the stage of disease development and following-up results of different treatments such as drug application, radiation therapy, cryodestruction, and laser vaporization. The discovered peculiarities of OCT images for structural and functional imaging of biological tissues can be put as a basis for application of this method for diagnosing of pathology, guidance of treatment, estimation of its adequacy and assessing of the healing process.

Paper Details

Date Published: 30 April 1999
PDF: 12 pages
Proc. SPIE 3598, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III, (30 April 1999); doi: 10.1117/12.347477
Show Author Affiliations
Natalia D. Gladkova, Nizhny Novgorod Medical Academy (Russia)
Natalia M. Shakhova, Nizhny Novgorod Medical Academy (Russia)
Andrei Shakhov, Nizhny Novgorod Medical Academy (Russia)
Galina P. Petrova, Nizhny Novgorod Medical Academy (Russia)
Elena Zagainova, Nizhny Novgorod Medical Academy (Russia)
Ludmila Snopova, Nizhny Novgorod Medical Academy (Russia)
Irina N. Kuznetzova, Nizhny Novgorod Regional Hospital (Russia)
Yuri Chumakov, Nizhny Novgorod Regional Hospital (Russia)
Felix I. Feldchtein, Institute of Applied Physics (United States)
Valentin M. Gelikonov, Institute of Applied Physics (Russia)
Grigory V. Gelikonov, Institute of Applied Physics (Russia)
Vladislav A. Kamensky, Institute of Applied Physics (Russia)
Roman V. Kuranov, Institute of Applied Physics (Russia)
Alexander M. Sergeev, Institute of Applied Physics (Russia)

Published in SPIE Proceedings Vol. 3598:
Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III
Valery V. Tuchin; Joseph A. Izatt, Editor(s)

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