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Proceedings Paper

High-resolution imaging of neoplastic lesions using optical coherence tomography
Author(s): Constantinos Pitris; Annekathryn Goodman; Stephen A. Boppart; Wolfgang Drexler; Christine Jesser; Debra L. Stamper; Mark E. Brezinski; James G. Fujimoto
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Paper Abstract

A technology capable of imaging tissue, at or near the cellular level, could lead to the detection of neoplasias at earlier stages than currently possible. This could significantly improve patient outcomes, since once cancer becomes metastatic, cure is difficult. Optical coherence tomography (OCT), a recently developed imaging technology, has ben shown to achieve resolution in the cellular and subcellular range, and it could improve the diagnostic range of clinical imaging procedures. To assess the clinical applicability of OCT, neoplastic specimens from the urinary, gastrointestinal and female reproductive tract were imaged. Sharp differentiation of structures included the mucosa/submucosal/muscularis boundaries, epithelium, glands, supportive tissue, and intramural cysts. The ability of optical coherence tomography to image tissue microstructure at or near the cellular level make it a potentially powerful technology for minimally invasive assessment of tissue microstructure. The resolution of optical coherence tomography, which is greater than any current clinical imaging modality, make it particularly attractive for the assessment of early neoplastic changes.

Paper Details

Date Published: 30 April 1999
PDF: 7 pages
Proc. SPIE 3598, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III, (30 April 1999); doi: 10.1117/12.347476
Show Author Affiliations
Constantinos Pitris, Massachusetts Institute of Technology (United States)
Annekathryn Goodman, Massachusetts General Hospital and Harvard Medical School (United States)
Stephen A. Boppart, Massachusetts Institute of Technology and Massachusetts General Hospital (United States)
Wolfgang Drexler, Massachusetts Institute of Technology (Austria)
Christine Jesser, Massachusetts Institute of Technology (United States)
Debra L. Stamper, King's College (United States)
Mark E. Brezinski, Massachusetts General Hospital and Harvard Medical School (United States)
James G. Fujimoto, Massachusetts Institute of Technology (United States)


Published in SPIE Proceedings Vol. 3598:
Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III
Valery V. Tuchin; Joseph A. Izatt, Editor(s)

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