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Proceedings Paper

Detection of carbon monoxide from biological tissue using difference frequency generation in periodically poled lithium niobate near 4.6 μm
Author(s): Yuji Morimoto; Jens Klattenhoff; William Durante; David G. Lancaster; Robert F. Curl; Frank K. Tittel
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Paper Abstract

A mid-IR gas sensor using difference frequency generation was developed to measure trace levels of biological carbon monoxide (CO). A periodically-poled lithium niobate crystal is pumped by a continuous wave Ti:Sapphire laser and a compact diode pumped Nd:YAG laser operating at 864.86 and 1064.6 nm, respectively. The strong IR transition R(6) at 2169.2 cm-1 is chosen for convenient CO detection without interference from other gas species. Carbon monoxide is collected and flowed into a multipass cell with an effective optical path length of 18.3 m. Using such an experimental arrangement, we detected the generation of CO at levels of 30 ppb during a 30 min period from living vascular smooth muscle cells in basal state.

Paper Details

Date Published: 21 April 1999
PDF: 6 pages
Proc. SPIE 3603, Systems and Technologies for Clinical Diagnostics and Drug Discovery II, (21 April 1999); doi: 10.1117/12.346754
Show Author Affiliations
Yuji Morimoto, Rice Univ. (United States)
Jens Klattenhoff, Rice Univ. (United States)
William Durante, Baylor College of Medicine (United States)
David G. Lancaster, Rice Univ. (United States)
Robert F. Curl, Rice Univ. (United States)
Frank K. Tittel, Rice Univ. (United States)


Published in SPIE Proceedings Vol. 3603:
Systems and Technologies for Clinical Diagnostics and Drug Discovery II
Gerald E. Cohn; John C. Owicki, Editor(s)

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