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Proceedings Paper

Mach-Zehnder-type evanescent wave biosensor in ion-exchanged glass using periodically segmented waveguide
Author(s): Zeev Weissman; E. Brand; I. Tsimberov; David Brooks; Shlomo Ruschin; Doron Goldberg
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Paper Abstract

Integratred optical Mach-Zehnder interferometric bio-sensors have been implemented in planar glass, by using ion-exchange waveguides. To simplify the fabrication of the sensors, periodically segmented waveguide has been used as the sensing arm, thus avoiding the need to open a sensing window over this arm. To evaluate the device performance, we performed two types of measurements. First, we measured the glucose concentration in a solution. The resulting sensitivity was less than 1 g/l, corresponding to less than 10-4 in the cover index, for a sensor with a 1 cm long sensing arm, having a segmentation duty-cycle of (eta) equals 0.5. Second, we measured the thickness sensitivity, with respect to the adsorption of avidin molecules onto the glass substrate. The resulting thickness resolution was about 1 Angstrom. Considering that the avidin concentration in the buffer solution was 2.5 (mu) g/mL, that the full thickness of the avidin layer was 2.5 nm, and that the layer buildup time was 7 min., the corresponding sensitivity for the avidin sensor is about 0.25 nM/hr.

Paper Details

Date Published: 21 April 1999
PDF: 7 pages
Proc. SPIE 3596, Specialty Fiber Optics for Medical Applications, (21 April 1999); doi: 10.1117/12.346721
Show Author Affiliations
Zeev Weissman, Tel Hai Academic College (Israel)
E. Brand, Tel Aviv Univ. (Israel)
I. Tsimberov, Tel Aviv Univ. (Israel)
David Brooks, Tel Aviv Univ. (Israel)
Shlomo Ruschin, Tel Aviv Univ. (Israel)
Doron Goldberg, Migal Research Ctr. (Israel)


Published in SPIE Proceedings Vol. 3596:
Specialty Fiber Optics for Medical Applications
Abraham Katzir; James A. Harrington, Editor(s)

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