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Proceedings Paper

Monitoring the diffusion of topically applied drugs through human and pig skin using fiber evanescent wave spectroscopy (FEWS)
Author(s): Juergen Spielvogel; Susanne Reuter; Raimund Hibst; Abraham Katzir
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Paper Abstract

The objective of this study was to examine if the diffusion process of topically applied drugs can reliably be monitored using FEWS in respect to timely distribution of the drug and chemical alterations of the drug during the diffusion process. In order to do this, recently excised human and pig skin was cut into slices of different thickness while also taking into account the different layers skin is composed of (e.g. Dermis, Stratum Corneum). These layers were first characterized spectroscopically and optically using a microscope before the drug itself was applied topically. The diffusion process was monitored by placing the sample on an ATR (attenuated total reflection) element. Time series from 1 - 4 hours were taken and the characteristic absorption bands of the drug were analyzed in the mid-infrared. By using a first order approach on Fick's diffusion equations (skin assumed to be homogeneous) we were able to fit these experimental values and to obtain diffusion constants, e.g. for water at 3376 cm-1 in the order of 10-5 cm2/s, which compare well with previously published values. The results indicate that this technique can be applied to the prediction of transdermal drug delivery.

Paper Details

Date Published: 21 April 1999
PDF: 9 pages
Proc. SPIE 3596, Specialty Fiber Optics for Medical Applications, (21 April 1999); doi: 10.1117/12.346720
Show Author Affiliations
Juergen Spielvogel, Institut fuer Lasertechnologien in der Medizin und Messtechnik/Univ. Ulm (Germany)
Susanne Reuter, Institut fuer Lasertechnologien in der Medizin und Messtechnik/Univ. Ulm (Germany)
Raimund Hibst, Institut fuer Lasertechnologien in der Medizin und Messtechnik/Univ. Ulm (Germany)
Abraham Katzir, Tel Aviv Univ. (Israel)

Published in SPIE Proceedings Vol. 3596:
Specialty Fiber Optics for Medical Applications
Abraham Katzir; James A. Harrington, Editor(s)

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