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Proceedings Paper

Fiber optic evanescent wave spectroscopy (FEWS) for blood diagnosis: the use of polymer-coated AgClBr fibers and neural network analysis
Author(s): Osnat Eytan; Edward Bormashenko; Roman Pogreb; Semion Sutovski; Irena Vaserman; Ben-Ami Sela; Abraham Katzir
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Paper Abstract

Infrared spectral analysis of human blood serum was carried out using FTIR-FEWS (Fourier Transform Infrared Fiberoptic Evanescent Wave Spectroscopy). The fiberoptic sensor elements were short (10.5 cm) lengths of unclad AgClBr fibers of diameter 0.9 mm. In order to protect the fibers from interaction with the blood serum we developed a dip coating technique, which made it possible to control the coating thickness. Three polymer materials were tested: polysulfone, polystyrene and room temperature vulcanized silicone elastomer. It was found that layers of thickness 2 - 3 micrometer provide chemical protection, while making it possible to carry out FEWS measurements. The measured spectra were analyzed by neural network analysis, to predict the concentrations of urea, uric acid, cholesterol, total protein and cretonne. The predicted concentrations were compared with the results obtained using standard chemical analysis of the blood (SMAC) and good correlation was observed, with errors of only few percent.

Paper Details

Date Published: 21 April 1999
PDF: 8 pages
Proc. SPIE 3596, Specialty Fiber Optics for Medical Applications, (21 April 1999); doi: 10.1117/12.346718
Show Author Affiliations
Osnat Eytan, Tel Aviv Univ. (Israel)
Edward Bormashenko, College of Judea and Samaria (Israel)
Roman Pogreb, College of Judea and Samaria (Israel)
Semion Sutovski, College of Judea and Samaria (Israel)
Irena Vaserman, Tel-Aviv Univ. (Israel)
Ben-Ami Sela, Sheba Medical Ctr. (Israel)
Abraham Katzir, Tel Aviv Univ. (Israel)

Published in SPIE Proceedings Vol. 3596:
Specialty Fiber Optics for Medical Applications
Abraham Katzir; James A. Harrington, Editor(s)

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