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Proceedings Paper

In-vivo Raman spectroscopy of human skin: determination of the composition of natural moisturizing factor
Author(s): Peter J. Caspers; Gerald W. Lucassen; Rolf Wolthuis; Hajo A. Bruining; Gerwin J. Puppels
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Paper Abstract

Near IR confocal Raman spectroscopy is a non-invasive and non-destructive technique that can provide information about molecular structure and composition in vivo. It is therefore of great interest for skin research. Neither samples preparation nor the use of markers and dyes are required. High quality spectra of the skin can be obtained in several seconds to minutes. Here we present in vivo Raman spectra of the outermost skin layer: stratum corneum. The spectra are interpreted in terms of differences between the molecular composition of the stratum corneum at two different body locations.

Paper Details

Date Published: 9 April 1999
PDF: 4 pages
Proc. SPIE 3608, Biomedical Applications of Raman Spectroscopy, (9 April 1999); doi: 10.1117/12.345389
Show Author Affiliations
Peter J. Caspers, Erasmus Univ. Rotterdam and Univ. Hospital Rotterdam (Netherlands)
Gerald W. Lucassen, Philips Research Labs. (Netherlands)
Rolf Wolthuis, Erasmus Univ. Rotterdam and Univ. Hospital Rotterdam (Netherlands)
Hajo A. Bruining, Erasmus Univ. Rotterdam and Univ. Hospital Rotterdam (Netherlands)
Gerwin J. Puppels, Erasmus Univ. Rotterdam and Univ. Hospital Rotterdam (Netherlands)

Published in SPIE Proceedings Vol. 3608:
Biomedical Applications of Raman Spectroscopy
Michael D. Morris, Editor(s)

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