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Proceedings Paper

Cooperative response of keratinocytes and melanocytes to UV radiation during PUVA therapy
Author(s): Mikhail M. Stolnitz; Pavel V. Baskakov; Anna Yu. Peshkova
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Paper Abstract

The mathematical model of processes in UV-irradiated furocoumarin-sensitized epidermis is presented taking into account the mutual influence of keratinocytes and melanocytes populations. The model describes epidermis as a hierarchical structure on tissue (keratinocytes-melanocytes cooperation, melanin screen formation), cellular (proliferation and differentiation, transitions between subpopulations), subcellular (cell movement on mitotic cycle, generation, maturing and migration of melanosomes), and molecular (melanin synthesis, processes of DNA damage and repair, molecular signal transduction) levels.

Paper Details

Date Published: 4 March 1999
PDF: 6 pages
Proc. SPIE 3726, Saratov Fall Meeting '98: Light Scattering Technologies for Mechanics, Biomedicine, and Material Science, (4 March 1999); doi: 10.1117/12.341446
Show Author Affiliations
Mikhail M. Stolnitz, Saratov State Univ. (Russia)
Pavel V. Baskakov, Saratov State Univ. (Russia)
Anna Yu. Peshkova, Saratov State Univ. (Russia)


Published in SPIE Proceedings Vol. 3726:
Saratov Fall Meeting '98: Light Scattering Technologies for Mechanics, Biomedicine, and Material Science
Valery V. Tuchin; Vladimir P. Ryabukho; Dmitry A. Zimnyakov, Editor(s)

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