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Proceedings Paper

Optochemical nanosensors for intracellular chemical measurement
Author(s): Raoul Kopelman; Michael T. Miller; Murphy Brasuel; Heather A. Clark; Marion Hoyer; Martin A. Philbert
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Paper Abstract

The development of a submicron optical fiber `supertip' has provided advantages over previously produced submicron tips, such as facilitating insertion of these sensors into cells while minimizing damage to the cell membrane. Fiber optic ion correlation-based nanosensors for sodium, potassium and chloride employing these `supertips' have been applied to the monitoring of ion concentrations in single mouse oocytes. These sensors have also been used to monitor the effect of an ion channel-blocking agent. In order to address the challenge associated with single-cell simultaneous measurement of multiple analytes, the use of submicron optical fiber multiprobes has been explored.

Paper Details

Date Published: 23 February 1999
PDF: 8 pages
Proc. SPIE 3540, Chemical, Biochemical, and Environmental Fiber Sensors X, (23 February 1999); doi: 10.1117/12.339797
Show Author Affiliations
Raoul Kopelman, Univ. of Michigan (United States)
Michael T. Miller, Univ. of Michigan (United States)
Murphy Brasuel, Univ. of Michigan (United States)
Heather A. Clark, Univ. of Michigan (United States)
Marion Hoyer, Univ. of Michigan (United States)
Martin A. Philbert, Univ. of Michigan (United States)

Published in SPIE Proceedings Vol. 3540:
Chemical, Biochemical, and Environmental Fiber Sensors X
Robert A. Lieberman, Editor(s)

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