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Proceedings Paper

Electromagnetic simulation of laser-induced fluorescence in bronchial tissue and predicted optical scattering behavior
Author(s): Karl J. Bamford; Jim James; Hugh Barr M.D.; Ralph P. Tatam
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Paper Abstract

Previous measurement by Qu et al, of laser-induced fluorescence in bronchus tissue are simulated using an electromagnetic (EM) scattering model. The EM parameters derived indicate that the changes in the epithelium thickness with carcinoma in situ can be detected with an optical radar process, hence providing an early detection of cancer. Further simulation using the EM model indicates various practical methods of extracting the thickness changes. These include frequency modulated continuous wave optical radar, multilaser continuous wave radar and low coherence interferometry. Initial optical experiments and calculations clarify which method is likely to lead to the development of endoscope instrumentation, but the availability of suitable optical components is a major consideration. Some early interferometry results indicate that a resolution of at least 40 micrometers can be readily reached for histological imaging. For 10 micrometers cell resolution, additional techniques are required.

Paper Details

Date Published: 12 February 1999
PDF: 11 pages
Proc. SPIE 3567, Optical and Imaging Techniques for Biomonitoring IV, (12 February 1999); doi: 10.1117/12.339190
Show Author Affiliations
Karl J. Bamford, Cranfield Univ. (United Kingdom)
Jim James, Cranfield Univ. (United Kingdom)
Hugh Barr M.D., Gloucester Royal Hospital (United Kingdom)
Ralph P. Tatam, Cranfield Univ. (United Kingdom)

Published in SPIE Proceedings Vol. 3567:
Optical and Imaging Techniques for Biomonitoring IV
Marco Dal Fante; Hans-Jochen Foth; Neville Krasner M.D.; Renato Marchesini; Halina Podbielska M.D., Editor(s)

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