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Proceedings Paper

Early diagnosis of gastric cancer with laser-induced fluorescence
Author(s): Alexander Y. Joffe; Valeriy F. Sayenko; Nikolay A. Denisov; Sergiy M. Dets; Alexander N. Buryi
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Paper Abstract

Optical biopsy of stomach mucosa was performed afterwards oral administration of encapsulated hyperflav (single dose was chosen to provide 0.1 - 0.15 mg/kg b.w.) A sufficient fluorescence contrast of suspicions versus normal tissue was obtained after incubation time from 4 to 10 hours. Fluorescence was induced by He - Cd laser coupled to fiber optic probe inserted into a biopsy channel of the endoscope. Fluorescent spectra were recorded in the range from 500 nm up to 700 nm with 2 nm resolution. We took two groups of patients with benign and malignant ulcer of the stomach and erosive gastritis. The first group consisted of 59 patients (male/female 36/23) was carried out with optical biopsy of stomach mucosa. The second group consisted of 60 patients (male/female 39/21) was carried out by routine method: gastroscopy and biopsy from 5 - 7 places of macroscopically changed mucosa.

Paper Details

Date Published: 12 February 1999
PDF: 8 pages
Proc. SPIE 3567, Optical and Imaging Techniques for Biomonitoring IV, (12 February 1999); doi: 10.1117/12.339186
Show Author Affiliations
Alexander Y. Joffe, Institute of Clinical and Experimental Surgery (Ukraine)
Valeriy F. Sayenko, Institute of Clinical and Experimental Surgery (Ukraine)
Nikolay A. Denisov, National Technical Univ. of Ukraine (Ukraine)
Sergiy M. Dets, Simon Fraser Univ. (Canada)
Alexander N. Buryi, Institute of Clinical and Experimental Surgery (Ukraine)

Published in SPIE Proceedings Vol. 3567:
Optical and Imaging Techniques for Biomonitoring IV
Marco Dal Fante; Hans-Jochen Foth; Neville Krasner M.D.; Renato Marchesini; Halina Podbielska M.D., Editor(s)

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