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Proceedings Paper

Laser-excited autofluorescence for discrimination of atherosclerosis
Author(s): Mersini I. Makropoulou; H. Drakaki; Nikoletta Anastasopoulou; Y. S. Raptis; Alexander A. Serafetinides; A. Pafiti; B. Tsiligiris; B. Arapoglou; P. Demakakos
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Paper Abstract

Experiments on atherosclerotic plaque diagnosis were carried out using laser induced fluorescence (LIF) spectroscopy on carotid plaque specimens. The excitation laser was a nitrogen laser, emitting pulses at a wavelength of 337 nm. Over 10 samples were examined in vitro and several spectra were obtained from each sample. Results were compared with conventional clinical techniques, such as histopathological diagnosis, which showed three areas of different composition on the pathological samples: fibrous tissue, lipid constituents and calcified plaque. An effort was made to distinguish the composition of the sample from the obtained spectra. Also, the results were compared with our previous work using longer excitation wavelengths. Spectral morphology of UV excited fluorescence reveals multi-peaks lineshapes, as a result of the superposition of different tissue chromophore signals. However, there was no observed specific wavelength where spectra corresponding to fibrous tissue, calcified tissue and lipid constituents have peaks.

Paper Details

Date Published: 4 February 1999
PDF: 8 pages
Proc. SPIE 3564, Medical Applications of Lasers in Dermatology, Cardiology, Ophthalmology, and Dentistry II, (4 February 1999); doi: 10.1117/12.339140

Published in SPIE Proceedings Vol. 3564:
Medical Applications of Lasers in Dermatology, Cardiology, Ophthalmology, and Dentistry II
Gregory B. Altshuler; Stefan Andersson-Engels; Reginald Birngruber; Peter Bjerring; Adolf Friedrich Fercher; Herbert J. Geschwind; Raimund Hibst; Herbert Hoenigsmann; Frederic Laffitte; Hericus J. C. M. Sterenborg, Editor(s)

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