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Proceedings Paper

Type III photosensitization: attempt for quantification and a way toward new sensitizers
Author(s): Tamas Kriska; Judit Jakus; Agnes Keszler; Rozalia Vanyur; Andras Nemeth; Dezso Gal
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Paper Abstract

Earlier results studying the effect of excited triplet photosensitizer on the zymosan-stimulated and luminol- dependent chemiluminescence of macrophages have been quantitatively re-evaluated and rate constant data indicate that the effect is due to triplet-doublet interactions between sensitizer and free radicals generated. Such interactions, named Type III mechanism, compete with Type I and Type II mechanisms depending on the experimental environment. This suggestion resulted in the synthesis of new sensitizers being the first members of the Antioxidant Carrier Sensitizer (ACS) group of molecules. According to preliminary experiments the PDT treatment of tumor bearing mice seems promising with two of such compounds which demonstrate an inhibitory effect in chemical systems already in their ground state.

Paper Details

Date Published: 3 February 1999
PDF: 7 pages
Proc. SPIE 3563, Photochemotherapy of Cancer and Other Diseases, (3 February 1999); doi: 10.1117/12.339133
Show Author Affiliations
Tamas Kriska, Institute of Chemistry (Hungary)
Judit Jakus, MTA (Hungary)
Agnes Keszler, Institute of Chemistry (Hungary)
Rozalia Vanyur, Institute of Chemistry (Hungary)
Andras Nemeth, Institute of Chemistry (Russia)
Dezso Gal, Institute of Chemistry (Hungary)


Published in SPIE Proceedings Vol. 3563:
Photochemotherapy of Cancer and Other Diseases
Benjamin Ehrenberg; Kristian Berg, Editor(s)

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