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Proceedings Paper

Cooperative effects of photosensitized cell killing
Author(s): Jostein Dahle; Even Angel-Petersen; Saulius Bagdonas; Harald B. Steen; Johan Moan
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Paper Abstract

MDCK II cells in colonies of eight cells and in confluent monolayers were treated with two different sensitizers and blue light. In both cases cooperation between the treated cells were detected. Cells photosensitized with Photofrin died by necrosis after irradiation, while cells photosensitized with tetra(3-hydroxyphenyl)porphyrin died by apoptosis. The cooperative interactions between the cells are contrary to one of the fundamental paradigms of radiation biology, namely that the targets of radiation are independent of each other.

Paper Details

Date Published: 3 February 1999
PDF: 5 pages
Proc. SPIE 3563, Photochemotherapy of Cancer and Other Diseases, (3 February 1999); doi: 10.1117/12.339127
Show Author Affiliations
Jostein Dahle, The Norwegian Radium Hospital (Norway)
Even Angel-Petersen, The Norwegian Radium Hospital (Norway)
Saulius Bagdonas, The Norwegian Radium Hospital (Lithuania)
Harald B. Steen, The Norwegian Radium Hospital (Norway)
Johan Moan, The Norwegian Radium Hospital (Norway)

Published in SPIE Proceedings Vol. 3563:
Photochemotherapy of Cancer and Other Diseases
Benjamin Ehrenberg; Kristian Berg, Editor(s)

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