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Proceedings Paper

Experimental study of PDT with aluminum sulphophthalocyanine using sodium ascorbate and hyperbaric oxygenation
Author(s): Gennadii A. Meerovich; Nadezgda L. Torshina; Victor B. Loschenov; Alexander A. Stratonnikov; Anna I. Volkova; Georgy N. Vorozhtsov; Oleg L. Kaliya; Eugeny A. Lukyanets; Boris Ya. Kogan; Alexander V. Butenin; Eugenia A. Kogan; Olga P. Gladskikh; Larisa N. Polyakova
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Paper Abstract

It is well known that sulphophthalocyanine derivatives under laser irradiation induce photochemical reaction of II type with generation of cytotoxic agent - singlet oxygen. The combination of phthalocyanine and exogenic reductant - sodium ascorbate may also induce other reactions, involving the formation of free radicals, and thus intensify the antitumor effect. To improve the results of PDT we used the additional injection of sodium ascorbate, the hyperbaric oxygenation and different regimes of laser irradiation. We conducted the experimental study on 100 white mice with Erlich carcinoma. Macroscopic and microscopic data showed that sodium ascorbate significantly increases the effect of PDT in comparison with control group due to the higher tumor damage, vascular alterations, inhibition of cell proliferation and stimulation of antitumor desmoplastic reaction.

Paper Details

Date Published: 3 February 1999
PDF: 9 pages
Proc. SPIE 3563, Photochemotherapy of Cancer and Other Diseases, (3 February 1999); doi: 10.1117/12.339120
Show Author Affiliations
Gennadii A. Meerovich, General Physics Institute (Russia)
Nadezgda L. Torshina, General Physics Institute (Russia)
Victor B. Loschenov, General Physics Institute (Russia)
Alexander A. Stratonnikov, General Physics Institute (Russia)
Anna I. Volkova, General Physics Institute (Russia)
Georgy N. Vorozhtsov, Organic Intermediates and Dyes Institute (Russia)
Oleg L. Kaliya, Organic Intermediates and Dyes Institute (Russia)
Eugeny A. Lukyanets, Organic Intermediates and Dyes Institute (Russia)
Boris Ya. Kogan, Organic Intermediates and Dyes Institute (Russia)
Alexander V. Butenin, Organic Intermediates and Dyes Institute (Russia)
Eugenia A. Kogan, Sechenov Moscow Medical Academy (Russia)
Olga P. Gladskikh, Sechenov Moscow Medical Academy (Russia)
Larisa N. Polyakova, Sechenov Moscow Medical Academy (Russia)

Published in SPIE Proceedings Vol. 3563:
Photochemotherapy of Cancer and Other Diseases
Benjamin Ehrenberg; Kristian Berg, Editor(s)

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