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Proceedings Paper

Characterization of the cellular uptake of 5-aminolevulinic acid
Author(s): Eva Rud; Kristian Berg
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Paper Abstract

Photodynamic therapy with 5-aminolevulinic acid (5-ALA) is a promising alternative treatment for several types of cancer. This work represents a first approach to characterize the transport system for 5-ALA in human cancer cells, using WiDr cells from a primary adenocarcinoma of the rectosigmoid colon as a model system. The transport of 5-ALA in WiDr was found to be dependent on pH and temperature, and partially inhibited by inhibitors of the energetic metabolism. Although WiDr was shown to express System A, a common transport system for small aliphatic amino acids, the transport of 5-ALA in WiDr was not found to be mediated by this system.

Paper Details

Date Published: 3 February 1999
PDF: 10 pages
Proc. SPIE 3563, Photochemotherapy of Cancer and Other Diseases, (3 February 1999); doi: 10.1117/12.339116
Show Author Affiliations
Eva Rud, The Norwegian Radium Hospital (Norway)
Kristian Berg, The Norwegian Radium Hospital (Norway)

Published in SPIE Proceedings Vol. 3563:
Photochemotherapy of Cancer and Other Diseases
Benjamin Ehrenberg; Kristian Berg, Editor(s)

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