Share Email Print

Proceedings Paper

Multifrequency YAG:Nd laser for diagnosis of malignant tumors
Author(s): Asatur A. Lalayan; Lusine Aydinyan; Ishkhan G. Harutyunyan; Hayro M. Galstian
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

The spectral peculiarities of normal and tumor human tissues of different localization after sensitization by sodium fluorescein has been studied with help of multifrequency YAG:Nd laser. Fluorescence spectra of normal human tissue and breast, stomach, intestine, skin cancer at 355, 440 nm laser excitation were registered. The pharmacokinetic behavior of sodium fluorescein in normal and different tumor tissues has been investigated. The optimal time for diagnosis (12 - 18 hours after drug injection) was determined. The intensification of tumor tissue autofluorescence decreasing after sensitization of organisms by tumor seeking dye was observed. The electron excitation energy transfer from NAD(P)H to endogen chromophores or dyes localized in tumor has been discussed as possible reason of the observed phenomenon.

Paper Details

Date Published: 19 January 1999
PDF: 6 pages
Proc. SPIE 3568, Optical Biopsies and Microscopic Techniques III, (19 January 1999); doi: 10.1117/12.336817
Show Author Affiliations
Asatur A. Lalayan, Yerevan State Univ. (Armenia)
Lusine Aydinyan, Yerevan State Univ. (Armenia)
Ishkhan G. Harutyunyan, Yerevan State Univ. (Armenia)
Hayro M. Galstian, Yerevan State Univ. (Armenia)

Published in SPIE Proceedings Vol. 3568:
Optical Biopsies and Microscopic Techniques III
Irving J. Bigio; Herbert Schneckenburger; Jan Slavik; Katarina Svanberg; Pierre M. Viallet, Editor(s)

© SPIE. Terms of Use
Back to Top