Share Email Print
cover

Proceedings Paper

Tissue diagnostics using fiber optic FTIR spectroscopy
Author(s): Uwe Bindig; Wolfgang Waesche; K. Liebold; Harald Winter; Ulrich M. Gross; P. Frege; G. Mueller
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

The infrared spectrum of biological tissue is due to the 'microheterogenous' composition as a whole and is based on complex vibrational modes. In detail, the spectrum represents the biochemical status resulting from a combination of the structural framework of tissues together with the biological active compounds of metabolism. According to the literature, the main IR-spectroscopic differences are to be expected by the characteristic spectral pattern which is located at the 'fingerprint' region (1500 - 1000 cm-1). In order to design and develop an endoscopic system for the in vivo identification of healthy and malignant tissue FTIR- measurements were carried out using a fiberoptic device. The source of IR-radiation can be either the FTIR-spectrometer or tunable IR-diode lasers. Fiberoptic IR-spectra obtained using the attenuated total reflectance (ATR) and reflection mode were compared to spectra resulting from the FTIR- microspectroscopic measurements.

Paper Details

Date Published: 19 January 1999
PDF: 8 pages
Proc. SPIE 3568, Optical Biopsies and Microscopic Techniques III, (19 January 1999); doi: 10.1117/12.336815
Show Author Affiliations
Uwe Bindig, Laser- und Medizin-Technologie gGmbH (Germany)
Wolfgang Waesche, Univ. Hospital Charite/Humboldt Univ. zu Berlin (Germany)
K. Liebold, Laser- und Medizin-Technologie gGmbH (Germany)
Harald Winter, Laser- und Medizin-Technologie gGmbH (Germany)
Ulrich M. Gross, Univ. Hospital Benjamin Franklin/Freie Univ. Berlin (Germany)
P. Frege, Univ. Hospital Benjamin Franklin/Freie Univ. Berlin (Germany)
G. Mueller, Laser- und Medizin-Technologie gGmbH and Freie Univ. Berlin (Germany)


Published in SPIE Proceedings Vol. 3568:
Optical Biopsies and Microscopic Techniques III
Irving J. Bigio; Herbert Schneckenburger; Jan Slavik; Katarina Svanberg; Pierre M. Viallet, Editor(s)

© SPIE. Terms of Use
Back to Top