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Proceedings Paper

Histological study of wound healing in rats following He-Ne and GaAlAs laser radiation
Author(s): Martha S. Ribeiro; Denise Maria Zezell; Edison P. Maldonado; Nilson D. Viera; Karin Carbone; Cleusa M. R. Pellegrini; Telma M. T. Zorn
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Paper Abstract

The influence of low-intensity linearly polarized visible ((lambda) equals 632.8 nm) and near infrared ((lambda) equals 797 nm) laser radiation on healing of skin wounds was compared histologically. Three round lesions measuring about 6 mm in diameter were created at the end of the spinal column of 20 rats divided in two groups of 10 animals by burning the rat back skin with liquid nitrogen. Lesions #1 and #2 were illuminated using He-Ne or GaAlAs laser radiation. The laser polarization was aligned with the rat spinal direction in lesion #1, lesion #2 with the perpendicular relative orientation and lesion #3 was not irradiated (control). The animals were irradiated with a total dose of 1 J/cm2 on day 3, 8, 11 and 14. After each irradiation, two rats from each group were killed to obtain morphological information. On day 17 the last rats were killed. The irradiated lesions presented a significant acceleration on the wound repair compared to the control. The results showed that the relative orientation of the electric field has an essential role on the healing process if exposure is visible light. On the other hand, no morphological difference was observed between illuminated lesions by near infrared radiation with respect to polarization orientation.

Paper Details

Date Published: 29 December 1998
PDF: 6 pages
Proc. SPIE 3569, Effects of Low-Power Light on Biological Systems IV, (29 December 1998); doi: 10.1117/12.334396
Show Author Affiliations
Martha S. Ribeiro, Instituto de Pesquisas Energeticas e Nucleares (Brazil)
Denise Maria Zezell, Instituto de Pesquisas Energeticas e Nucleares (Brazil)
Edison P. Maldonado, Instituto de Pesquisas Energeticas e Nucleares (Brazil)
Nilson D. Viera, Instituto de Pesquisas Energeticas e Nucleares (Brazil)
Karin Carbone, Univ. de Sao Paulo (Brazil)
Cleusa M. R. Pellegrini, Univ. de Sao Paulo (Brazil)
Telma M. T. Zorn, Univ. de Sao Paulo (Brazil)


Published in SPIE Proceedings Vol. 3569:
Effects of Low-Power Light on Biological Systems IV
Giovanni F. Bottiroli; Tiina I. Karu; Rachel Lubart, Editor(s)

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