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Proceedings Paper

Two- and three-dimensional optical tomography of finger joints for diagnostics of rheumatoid arthritis
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Paper Abstract

Rheumatoid arthritis (RA) is one of the most common diseases of human joints. This progressive disease is characterized by an inflammation process that originates in the inner membrane (synovalis) of the capsule and spreads to other parts of the joint. In early stages the synovalis thickness and the permeability of this membrane changes. This leads to changes in the optical parameters of the synovalis and the synovial fluid (synovia), which occupies the space between the bones. The synovia changes from a clear yellowish fluid to a turbid grayish substance. In this work we present 2 and 3-dimensional reconstruction schemes for optical tomography of the finger joints. Our reconstruction algorithm is based on the diffusion approximation and employs adjoint differentiation techniques for the gradient calculation of the objective function with respect to the spatial distribution of optical properties. In this way, the spatial distribution of optical properties within the joints is reconstructed with high efficiency and precision. Volume information concerning the synovial space and the capsula are provided. Furthermore, it is shown that small changes of the scattering coefficients can be monitored. Therefore, optical tomography has the potential of becoming a useful tool for the early diagnosis and monitoring of disease progression in RA.

Paper Details

Date Published: 30 December 1998
PDF: 10 pages
Proc. SPIE 3566, Photon Propagation in Tissues IV, (30 December 1998); doi: 10.1117/12.334363
Show Author Affiliations
Alexander D. Klose, SUNY/Brooklyn Health Science Ctr. (United States)
Andreas H. Hielscher, SUNY/Brooklyn Health Science Ctr. (United States)
Kenneth M. Hanson, Los Alamos National Lab. (United States)
Juergen Beuthan, Institut fuer Medizinische/Technische Physik und Lasermedizin/Freie Univ. Berlin (Germany)

Published in SPIE Proceedings Vol. 3566:
Photon Propagation in Tissues IV
David A. Benaron; Britton Chance; Marco Ferrari; Matthias Kohl-Bareis, Editor(s)

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