A miniaturized microanalytical device for the simultaneous monitoring of different metabolites was realized by assembling of a biosensor array produced by thin film technology with a flow-through cell produced by printed circuit board technology. The biosensor array comprises four working electrodes which can be individually configured. Glucose and lactate devices were made for whole blood monitoring. Ex vivo experiments, performed on animals, where the device was continuously operated in an extracorporeal undiluted heparinized blood stream without loss in sensitivity for 48 hours, gave close tracing to routinely used clinical analyzers by using one point in vitro calibration.

Date Published: 18 December 1998
PDF: 5 pages
Proc. SPIE 3539, Chemical Microsensors and Applications, (18 December 1998); doi: 10.1117/12.333753

Published in SPIE Proceedings Vol. 3539:
Chemical Microsensors and Applications
Stephanus Buettgenbach, Editor(s)