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Proceedings Paper

Combined effects of photodynamic and sonodynamic treatment on experimental skin cancer on C3H mice
Author(s): Zhao-Hui Jin; Norio Miyoshi; Kazumori Ishiguro; Izumi Maruyama; Isao Sakata; Keigo Takaoka; Takeshi Udagawa; Susumu Nakajima; Keichi Ueda; Fukuda Masaru; Masanobu Kumakiri
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Paper Abstract

In recent years, the effect of ultrasound (US) in combination with porphyrins such as a gallium-porphyrin complex (ATX-70) has been reported in the treatment of experimental cancers. Before clinical application of this method, further studies are needed. The transplanted squamous cell carcinomas (5CC) on C3H/He mice were irradiated by a tunable optical parametric oscillator (OPO) laser light or ultrasound, in the presence of several different photosensitizers. The tumor size and survival of mice after treatment were observed. Furthermore, we compared antitumor effects of combined irradiation of laser light and ultrasound with those of single laser light or ultrasound, in the presence of ATX-70 or a pheoforbide derivative (PH-1126). Besides PH-i 126 and ATX-70, the following sensitizers were tested: Photofrin II (Pf-II), hematoporphyrin oligomer (HpO). 5-aminolevulinic acid (5-ALA) and aluminum phthalocyanine tetrasuiphonate (AIPcS4). In the results, it was good effects of antitumor by the laser light treatment in the case of PH-1126 and AIPcS4, ATX-70, HpO nsd AIPcS4 produced betterantitumor effeets by irradiation with ultrasound. The antitumor effects of combined use of laser fight and ultrasound were stronger than those of single laser light or ultrasound in both cases of PH-i 126 and ATX-70. Key words: OPO laser light, ultrasound, PH-1126. ATX-70

Paper Details

Date Published: 2 November 1998
PDF: 7 pages
Proc. SPIE 3344, 1997 Shanghai International Conference on Laser Medicine and Surgery, (2 November 1998); doi: 10.1117/12.330180
Show Author Affiliations
Zhao-Hui Jin, Fukui Medical Univ. (Japan)
Norio Miyoshi, Fukui Medical Univ. (Japan)
Kazumori Ishiguro, Fukui Medical Univ. (Japan)
Izumi Maruyama, Toyo-Hakka Kogyo Ltd. (Japan)
Isao Sakata, Toyo-Hakka Kogyo Ltd. (Japan)
Keigo Takaoka, Ishikawajima Heavy Industries Co. Ltd. (Japan)
Takeshi Udagawa, Ishikawajima Heavy Industries Co. Ltd. (Japan)
Susumu Nakajima, Asahikawa Medical School (Japan)
Keichi Ueda, Fukui Medical Univ. (Japan)
Fukuda Masaru, Fukui Medical Univ. (Japan)
Masanobu Kumakiri, Fukui Medical Univ. (Japan)


Published in SPIE Proceedings Vol. 3344:
1997 Shanghai International Conference on Laser Medicine and Surgery

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