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Proceedings Paper

Numerical simulation and experimental study of time-resolved optical tomographic imaging
Author(s): H. J. Zhao; Feng Gao; Hanben Niu; Ji Li; Hai Zhang
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Paper Abstract

Near infra-red optical computerized tomographic imaging through a turbid tissue by using time-resolved measurement has been gaining widespread attentions from the field of biomedical research for its non-invasiveness and ability of disclosing the functional information of tissue. A variety of techniques, aimed at implementing a clinically-useful system, have been proposed for eliminating the obstacles arising from multiple light scattering of biological tissue. Among these scheme, one of the primary goals has been to seek for a fast, effective and mathematically rigorous algorithm for the reconstruction tasks. In this paper we first present the basic principle of time-resolved optical tomography. The diffusion approximation-based photon transport model in a highly scattering tissue, which offers an advantage in computational speed in comparison with other stochastic models, and the procedure for solving this forward model by using the finite-element method are then accessed. Theoretically, an iterative Newton-Raphson algorithm for solving the inverse problem is introduced based on the implicit calculation of Jacobian of the forward operator. Numerically simulated images of absorbers embedded in a homogeneous tissue sample are reconstructed from either mean-time-of-flight or integrated intensity data for the verification of the approach. Finally, the experiment setup which are under construction in our Lab is described in detail.

Paper Details

Date Published: 4 December 1998
PDF: 6 pages
Proc. SPIE 3491, 1998 International Conference on Applications of Photonic Technology III: Closing the Gap between Theory, Development, and Applications, (4 December 1998); doi: 10.1117/12.328706
Show Author Affiliations
H. J. Zhao, Xi'an Institute of Optics and Precision Mechanics (China)
Feng Gao, Xi'an Institute of Optics and Precision Mechanics (China)
Hanben Niu, Xi'an Institute of Optics and Precision Mechanics (China)
Ji Li, Xi'an Institute of Optics and Precision Mechanics (China)
Hai Zhang, Xi'an Institute of Optics and Precision Mechanics (China)


Published in SPIE Proceedings Vol. 3491:
1998 International Conference on Applications of Photonic Technology III: Closing the Gap between Theory, Development, and Applications
George A. Lampropoulos; Roger A. Lessard, Editor(s)

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