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Proceedings Paper

Monitoring of corneal allograft rejection using laser flare meter
Author(s): Tomasz Zarnowski; Dariusz Haszcz; Ewa Rakowska; Zbigniew Zagorski
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Paper Abstract

The purpose of this study was to quantify noninvasively, with the use of laser-flare meter the alterations of the blood-aqueous barrier following penetrating keratoplasty. This could diagnose objectively disruption of this barrier in eyes with early allograft rejection, possible even before manifestation of the clinical signs and would help to monitor the efficacy of the treatment. We used the laser flare-meter (Kowa FM-500) to investigate alteration of the blood-aqueous barrier following uncomplicated penetrating keratoplasty (PK) and in corneal allograft rejection. Examination was performed in 50 eyes of 48 patients after uncomplicated PK (7 days to 12 months after PK), in 20 normal control eyes and in 8 patients with acute allograft rejection. Flare values after uncomplicated keratoplasty slowly decreased in time reaching nearly control values 6 - 12 months postoperatively. They were considerably higher for acute allograft rejection compared to eyes following uncomplicated PK and normal control group. Actually, they tended to diminish gradually after systemic and topical administration of steroids and/or immunosuppressants. Application of laser tyndalometry has been proven to be highly useful in the follow up of patients after perforating keratoplasty-especially high risk grafts, it helps to detect objectively early allograft rejection and is beneficial in monitoring the effectiveness of the treatment.

Paper Details

Date Published: 22 October 1998
PDF: 6 pages
Proc. SPIE 3579, Ophthalmic Measurements and Optometry, (22 October 1998); doi: 10.1117/12.328309
Show Author Affiliations
Tomasz Zarnowski, Lublin Univ. School of Medicine (Poland)
Dariusz Haszcz, Lublin Univ. School of Medicine (Poland)
Ewa Rakowska, Lublin Univ. School of Medicine (Poland)
Zbigniew Zagorski, Lublin Univ. School of Medicine (Poland)

Published in SPIE Proceedings Vol. 3579:
Ophthalmic Measurements and Optometry
Maksymilian Pluta; Mariusz Szyjer, Editor(s)

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