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Proceedings Paper

Drug and light dose dependence of PDT on pancreatic cancer cells in vitro
Author(s): Konstantinos N. Halkiotis; L. D. Manolopoulos; Nikolaos K. Uzunoglou; Dido M. Yova
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Paper Abstract

Photodynamic therapy (PDT) is a promising new treatment for a variety of malignant tumors. Recently, PDT has been investigated as an alternative treatment for pancreatic carcinoma. The selection of photosensitizer and laser light are equally important for the treatment efficacy. The purpose of this study is to evaluate drug and light dose dependence of photodynamic effect in pancreatic cancer cells. Zinc tetrasulfonated phthalocyanines used as photosensitizer and a novel diode laser system terminated at alight shaping diffuser was used as light source. Viability was measured 24 and 72 hours after treatment and almost 100 percent lethality levels were achieved, by using low light doses independently of drug concentration. The results are discussed in correlation with light and drug doses.

Paper Details

Date Published: 14 July 1998
PDF: 5 pages
Proc. SPIE 3423, Second GR-I International Conference on New Laser Technologies and Applications, (14 July 1998); doi: 10.1117/12.316629
Show Author Affiliations
Konstantinos N. Halkiotis, National Technical Univ. of Athens (Greece)
L. D. Manolopoulos, Univ. of Athens (Greece)
Nikolaos K. Uzunoglou, National Technical Univ. of Athens (Greece)
Dido M. Yova, National Technical Univ. of Athens (Greece)


Published in SPIE Proceedings Vol. 3423:
Second GR-I International Conference on New Laser Technologies and Applications
Alexis Carabelas; Paolo Di Lazzaro; Amalia Torre; Giuseppe Baldacchini, Editor(s)

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