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Proceedings Paper

Laser-based assessment of lipid peroxidation in humans
Author(s): Gianfranco Giubileo
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Paper Abstract

Infrared absorption spectroscopy can be performed at very high resolution by tunable diode laser (TDL) based optical systems for any gas with well resolved absorption spectra. In a double beam setup atmospheric trace gas concentration can be measured down to ppb levels. The analysis of trace gases may have useful applications in detecting chemicals in the human breath for non invasive medical diagnostic. The capability of TDL based breath analysis was well demonstrated by monitoring ammonia and methane. In the human body the formation of free radicals does induce oxidative degradation of polyunsaturated fatty acids (lipid peroxidation) which is a damage for cells and organs in the organism. Specific volatile hydrocarbons generated as end product by lipid peroxidation (LP) can be found inside circulating blood and expired breath. TDL based analysis of those specific hydrocarbons (ethane and pentane) in the expired breath can allow a non invasive assessment of the LP extent.

Paper Details

Date Published: 2 July 1998
PDF: 12 pages
Proc. SPIE 3405, ROMOPTO '97: Fifth Conference on Optics, (2 July 1998); doi: 10.1117/12.312823
Show Author Affiliations
Gianfranco Giubileo, ENEA (Italy)

Published in SPIE Proceedings Vol. 3405:
ROMOPTO '97: Fifth Conference on Optics
Valentin I. Vlad; Dan C. Dumitras, Editor(s)

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