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Proceedings Paper

Automated assessment of split lung functon in post-lung-transplant evaluation
Author(s): Jonathan G. Goldin; Matthew S. Brown; Michael F. McNitt-Gray; Lloyd E. Greaser; Katherine Martin; James W. Sayre; Denise R. Aberle
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Paper Abstract

The purpose of this work was to develop an automated technique for calculating dynamic lung attenuation changes, through a forced expiratory maneuver, as a measure of split lung function. A total of ten patients post single lung transplantation (SLT) for emphysema were imaged using an Electron Beam CT Scanner; three were studied twice following stent placement. A single-slice flow study, using 100 msec exposures and 3 mm collimation, was performed at the level of the anastomosis during a forced expiration. Images were acquired every 500 msec for the first 3 seconds and every second for the last 4 seconds. An automated, knowledge-based system was developed to segment the chest wall, mediastinum, large airways and lung parenchyma in each image. Knowledge of the expected size, shape, topology and X-ray attenuation of anatomical structures were used to guide image segmentation involving attenuation thresholding, region-growing and morphology. From the segmented left and right parenchyma, the system calculated median attenuation (HU) and cross-sectional areas. These results were plotted against time for both the native and transplanted lungs. In five patients, significant shift of the attenuation/time curve to the right (slower flow) was detected, although the end expiration attenuation was not different. Following stent placement the curve shifted back to the left (faster flow).

Paper Details

Date Published: 3 July 1998
PDF: 10 pages
Proc. SPIE 3337, Medical Imaging 1998: Physiology and Function from Multidimensional Images, (3 July 1998); doi: 10.1117/12.312573
Show Author Affiliations
Jonathan G. Goldin, UCLA School of Medicine (United States)
Matthew S. Brown, UCLA School of Medicine (Australia)
Michael F. McNitt-Gray, UCLA School of Medicine (United States)
Lloyd E. Greaser, UCLA School of Medicine (United States)
Katherine Martin, UCLA School of Medicine (United States)
James W. Sayre, UCLA School of Medicine (United States)
Denise R. Aberle, UCLA School of Medicine (United States)


Published in SPIE Proceedings Vol. 3337:
Medical Imaging 1998: Physiology and Function from Multidimensional Images
Eric A. Hoffman, Editor(s)

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