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Proceedings Paper

Subtle volume differences in brain parenchyma of children surviving medulloblastoma
Author(s): Wilburn E. Reddick; Raymond K. Mulhern; T. David Elkin; John O. Glass; James W. Langston
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Paper Abstract

The overriding incentive for accurate quantification of the functional status of children treated for brain tumors emerges from the clinician's desire to balance the efficacy and chronic toxicity of therapies used for the developing child. A hybrid combination of the Kohonen self-organizing map (SOM) for segmentation and a multilayer backpropagation (MLBP) neural network for classification removes observer variances to yield a reproducible and accurate identification of tissues. A group of 17 volunteers and 77 patients from a larger ongoing study of pediatric patients with brain tumors were used to investigate the sensitivity of segmented volumes to determine atrophy as measured by two radiologists. The atrophy study revealed a significant relationship for brain parenchyma, CSF and white matter volumes with atrophy while gray matter had no significant relationship. Brain parenchyma and subsequently white matter were found to be inversely proportional to increasing grades of atrophy. An additional study compared fifteen age-matched patients treated with irradiation and surgery with patients treated with surgery alone. The age-matched study of patients demonstrated that brain volumes in the irradiated patients were significantly decreased compared to those treated with surgery alone. Further investigation of this difference revealed that white matter was significantly reduced while gray matter was relatively unchanged.

Paper Details

Date Published: 3 July 1998
PDF: 7 pages
Proc. SPIE 3337, Medical Imaging 1998: Physiology and Function from Multidimensional Images, (3 July 1998); doi: 10.1117/12.312571
Show Author Affiliations
Wilburn E. Reddick, St. Jude Children's Research Hospital and Univ. of Memphis (United States)
Raymond K. Mulhern, St. Jude Children's Research Hospital (United States)
T. David Elkin, St. Jude Children's Research Hospital and Univ. of Memphis (United States)
John O. Glass, St. Jude Children's Research Hospital and Univ. of Memphis (United States)
James W. Langston, St. Jude Children's Research Hospital and Univ. of Tennessee (United States)


Published in SPIE Proceedings Vol. 3337:
Medical Imaging 1998: Physiology and Function from Multidimensional Images
Eric A. Hoffman, Editor(s)

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