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Proceedings Paper

Pharmacokinetic imaging of pediatric solid tumors
Author(s): Wilburn E. Reddick; Sihong Wang; Sue C. Kaste
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Paper Abstract

Previously developed empirical analyses of dynamic contrast- enhanced MR imaging (DEMRI) studies have provided a more quantitative and accurate measure of solid tumor response. However, empirically based methods do not generalize easily to other solid tumors, and changes in the parameters during therapy are hard to relate to physiological mechanisms. This study compares the kinetic parameters from a two-compartment pharmacokinetic (PK) model of MR contrast agent accumulation with disease free survival rates after surgery and investigates the serial changes in these parameters over the course of therapy in thirty-five patients with osteosarcoma. The PK model allowed us to directly determine the relationship between the first-order permeability rate constant (k21) of the model and histologic assessment of response. A Cox proportional hazards model was used to compare the average k21 immediately prior to surgery and was determined to be significantly related to disease free survival. A linear regression analysis between the average k21 at presentation and the resulting change in average k21 during therapy revealed a statistically significant relationship corresponding to greater delivery of contrast agent. Larger regional access at presentation corresponded to larger decreases in access during therapy, which is consistent with the hypothesis that greater regional access at presentation should correspond to greater response to the chemotherapeutic agents.

Paper Details

Date Published: 3 July 1998
PDF: 9 pages
Proc. SPIE 3337, Medical Imaging 1998: Physiology and Function from Multidimensional Images, (3 July 1998); doi: 10.1117/12.312557
Show Author Affiliations
Wilburn E. Reddick, St. Jude Children's Research Hospital and Univ. of Memphis (United States)
Sihong Wang, Univ. of Texas at Austin (United States)
Sue C. Kaste, St. Jude Children's Research Hospital (United States)

Published in SPIE Proceedings Vol. 3337:
Medical Imaging 1998: Physiology and Function from Multidimensional Images
Eric A. Hoffman, Editor(s)

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