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Proceedings Paper

Tissue temperatures attained in indocyanine-green infiltrated and noninfiltrated bovine eyelids using diode laser (805-nm) energy at 3, 5, and 7 watts
Author(s): John G. Kirkpatrick; Kenneth Eugene Bartels; D. Thomas Dickey; Ronald Powell; Steven A. Schafer; Jin Fu Zhou; James P. Wicksted
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Paper Abstract

Normal non-pigmented bovine eyelids in two Hereford cows under general anesthesia were treated with diode laser (805 nm) in a power range of 3 - 6.5 watts. Tissue temperatures were measured in areas infiltrated with 0.25% indocyanine green (ICG) solution and in non-infiltrated areas. Targeted tissue was laser treated at post-injection time intervals of 1 to 60 minutes. Temperatures were measured with a computerized temperature sensing program using hypodermic needle thermistors. Trial objectives were to establish power/chromophore concentration/time parameters to create tumor and peri-tumor tissue temperatures of 50 degrees Celsius without causing epidermal vaporization. Tissue temperature of 50 degrees Celsius has been established as the temperature producing coagulative necrosis of squamous cell carcinoma tumor tissue in 30 seconds. This temperature was produced in chromophore-enhanced tissue bit without repeatable confidence. Bovine ocular squamous cell carcinoma (BOSCC)-affected eyes and eyelids have been successfully treated with carbon dioxide focused and defocused laser with and without chromophore enhanced diode laser (805 nm) energy. The need for tumor staging and procedure standardization requires further investigation to determine laser power/chromophore concentration, and issue exposure times.

Paper Details

Date Published: 1 July 1998
PDF: 4 pages
Proc. SPIE 3245, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VIII, (1 July 1998); doi: 10.1117/12.312315
Show Author Affiliations
John G. Kirkpatrick, Oklahoma State Univ. College of Veterinary Medicine (United States)
Kenneth Eugene Bartels, Oklahoma State Univ. College of Veterinary Medicine (United States)
D. Thomas Dickey, Oklahoma State Univ. College of Veterinary Medicine (United States)
Ronald Powell, Oklahoma State Univ. College of Veterinary Medicine (United States)
Steven A. Schafer, Oklahoma State Univ. College of Veterinary Medicine (United States)
Jin Fu Zhou, Oklahoma State Univ. College of Veterinary Medicine (United States)
James P. Wicksted, Oklahoma State Univ. College of Veterinary Medicine (United States)


Published in SPIE Proceedings Vol. 3245:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VIII
Graham M. Watson; Harvey Lui; Lou Reinisch; Penny J. Smalley; Kenneth Eugene Bartels; R. Rox Anderson; Lawrence S. Bass; Kenneth Eugene Bartels; C. Gaelyn Garrett; Lloyd P. Tate; Sharon L. Thomsen; Reza S. Malek; Aaron P. Perlmutter; R. Rox Anderson; Lawrence S. Bass; C. Gaelyn Garrett; Kenton W. Gregory; Harvey Lui; Reza S. Malek; Aaron P. Perlmutter; Lou Reinisch; Penny J. Smalley; Lloyd P. Tate; Sharon L. Thomsen; Graham M. Watson, Editor(s)

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