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Proceedings Paper

Organ transplant tissue rejection: detection and staging by fluorescence spectroscopy
Author(s): Calum E. MacAulay; Peter D. Whitehead; Bruce McManus; Haishan Zeng; Janet Wilson-McManus; Nick MacKinnon; David C. Morgan; Chunming Dong; Paul Gerla; Jennifer Kenyon
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Paper Abstract

Patients receiving heart or other organ transplants usually require some level of anti-rejection drug therapy, most commonly cyclosporine. The rejection status of the organ must be monitored to determine the optimal anti-rejection drug therapy. The current method for monitoring post-transplant rejection status of heart transplant patients consists of taking biopsies from the right ventricle. In this work we have developed a system employing optical and signal-processing techniques that will allow a cardiologist to measure spectral changes associated with tissue rejection using an optical catheter probe. The system employs time gated illumination and detection systems to deal with the dynamic signal acquisition problems associated with in vivo measurements of a beating heart. Spectral data processing software evaluates and processes the data to produce a simple numerical score. Results of measurements made on 100 excised transplanted isograft and allograft rat hearts have demonstrated the ability of the system to detect the presence of rejection and to accurately correlate the spectroscopic results with the ISHLT (International Society for Heart and Lung Transplantation) stage of rejection determined by histopathology. In vivo measurements using a pig transplant model are now in process.

Paper Details

Date Published: 1 July 1998
PDF: 6 pages
Proc. SPIE 3245, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VIII, (1 July 1998); doi: 10.1117/12.312312
Show Author Affiliations
Calum E. MacAulay, British Columbia Cancer Agency (Canada)
Peter D. Whitehead, Biomax Technologies, Inc. (Canada)
Bruce McManus, Univ. of British Columbia (Canada)
Haishan Zeng, British Columbia Cancer Agency (Canada)
Janet Wilson-McManus, Univ. of British Columbia (Canada)
Nick MacKinnon, British Columbia Cancer Agency (Canada)
David C. Morgan, Biomax Technologies, Inc. (Canada)
Chunming Dong, Univ. of British Columbia (Canada)
Paul Gerla, Biomax Technologies, Inc. (Canada)
Jennifer Kenyon, Univ. of British Columbia (Canada)


Published in SPIE Proceedings Vol. 3245:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VIII
Graham M. Watson; Harvey Lui; Lou Reinisch; Penny J. Smalley; Kenneth Eugene Bartels; R. Rox Anderson; Lawrence S. Bass; Kenneth Eugene Bartels; C. Gaelyn Garrett; Lloyd P. Tate; Sharon L. Thomsen; Reza S. Malek; Aaron P. Perlmutter; R. Rox Anderson; Lawrence S. Bass; C. Gaelyn Garrett; Kenton W. Gregory; Harvey Lui; Reza S. Malek; Aaron P. Perlmutter; Lou Reinisch; Penny J. Smalley; Lloyd P. Tate; Sharon L. Thomsen; Graham M. Watson, Editor(s)

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