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Proceedings Paper

Image-guided MR spectroscopy VOI localization for longitudinal studies
Author(s): Steven L. Hartmann; Benoit M. Dawant; Mitchell H. Parks; Heide Schlack; Peter R. Martin
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Paper Abstract

Longitudinal magnetic resonance spectroscopy (MRS) studies require accurate repositioning of the volume of interest (VOI) over which measurements are made. In this work we present and evaluate a method for the image-guided repositioning of brain volumes of interest. The point-based registration technique we developed allows the repositioning to be performed on-line (i.e., while the patient is in the scanner). MR image volumes were acquired from six subjects, three scans each over the course of a month. During the first scan, two spectroscopy VOIs are visually selected: one in the frontal white matter, the other in the superior cerebellar vermis. The coordinates of 13 internal brain landmarks were also identified. During both subsequent scans, the same 13 landmarks were also identified, and the transformation that registers the first set of landmarks to the subsequent set is compared. This result is used to automatically map the position of the spectroscopy. VOIs from the first volume to the current volume. For the six subjects evaluated to date, we show an average repositioning error of the spectroscopy VOIs in the order of 1 mm. This accuracy allows us to conclude that any variation in the MR spectra are unlikely to be due to repositioning error.

Paper Details

Date Published: 24 June 1998
PDF: 11 pages
Proc. SPIE 3338, Medical Imaging 1998: Image Processing, (24 June 1998); doi: 10.1117/12.310916
Show Author Affiliations
Steven L. Hartmann, Vanderbilt Univ. (United States)
Benoit M. Dawant, Vanderbilt Univ. (United States)
Mitchell H. Parks, Vanderbilt Univ. (United States)
Heide Schlack, Vanderbilt Univ. (United States)
Peter R. Martin, Vanderbilt Univ. (United States)


Published in SPIE Proceedings Vol. 3338:
Medical Imaging 1998: Image Processing
Kenneth M. Hanson, Editor(s)

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