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Proceedings Paper

Motion-compensated blind deconvolution of scanning laser opthalmoscope imagery
Author(s): Nathan J. O'Connor; Dirk-Uwe G. Bartsch; William R. Freeman; Timothy J. Holmes
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Paper Abstract

A deconvolution algorithm for use with scanning laser ophthalmoscope (SLO) data is being developed. The SLO is fundamentally a confocal microscope in which the objective lens is the human ocular lens. 3D data is collected by raster scanning to form images at different depths in retinal and choroidal layers. In this way, 3D anatomy may be imaged and stored as a series of optical sections.Given the poor optical quality of the human lens and random eye motion during data acquisition, any deconvolution method applied to SLO data must be able to account for distortions present in the observed data. The algorithm presented compensates for image warping and frame-to-frame displacement due to random eye motion, smearing along the optic axis, sensor saturation, and other problems. A preprocessing step is first used to compensate for frame-to-frame image displacement. The image warping, caused by random eye motion during raster scanning, is corrected. Finally, a maximum likelihood based blind deconvolution algorithm is used to correct severe blurring along the optic axis. The blind deconvolution algorithm contains an iterative search for subpixel displacements remaining after image warping and frame-to-frame displacements are corrected. This iterative search is formulated to ensure that the likelihood functional is non-decreasing.

Paper Details

Date Published: 9 June 1998
PDF: 17 pages
Proc. SPIE 3261, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing V, (9 June 1998); doi: 10.1117/12.310540
Show Author Affiliations
Nathan J. O'Connor, Rensselaer Polytechnic Institute and AutoQuant Imaging Inc. (United States)
Dirk-Uwe G. Bartsch, Univ. of California/San Diego (United States)
William R. Freeman, Univ. of California/San Diego (United States)
Timothy J. Holmes, Rensselaer Polytechnic Institute and AutoQuant Imaging Inc. (United States)


Published in SPIE Proceedings Vol. 3261:
Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing V
Thomas Taiwei Lu; Carol J. Cogswell; Jeremy M. Lerner; Jose-Angel Conchello; Jeremy M. Lerner; Thomas Taiwei Lu; Tony Wilson, Editor(s)

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