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Proceedings Paper

Deep sclerectomy with and without implant: an in-vivo comparative study
Author(s): Mitsumo Yamamichi; Philippe Sourdille M.D.; Hassan Tahi; Valerie Jallet; Franck L. Villain; Francisco Fantes; Jean-Marie A. Parel
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Paper Abstract

Purpose: Establish the effects of pre-Descemetic sclero- keratectomy, a new nonpenetrating Deep-Sclerectomy filtration procedure, with and without crosslinked sodium hyaluronic acid (SKgel) implant in the rabbit animal model. Materials and Methods: Ten adult NZW rabbits had surgery only (group A) and 15 other had surgery and a crosslinked sodium hyaluronate implant inserted under the scleral flap (group B). Weekly intraocular pressure (IOP), outflow facility, and central and peripheral corneal thicknesses were measured in both the operated and the contralateral eye over a period of five months in Group A and six months in Group B. Results: IOP was consistently lower until POD 21 for Group A and POD 161 for Group B, respectively (P less than 0.05). Outflow facility was significantly higher than control eyes until POD 14 in Group A and until POD 84 in Group B. Peripheral corneal thickness returned to normal by POD 14 in Group A and POD 28 in Group B. By POD 35, there was no statistical significance between both groups in the mean of peripheral corneal thickness. Conclusion: Pre-Descemetic Sclero-Keratectomy with crosslinked sodium hyaluronate implant is effective in reducing IOP and safe operation in rabbit eyes.

Paper Details

Date Published: 1 June 1998
PDF: 6 pages
Proc. SPIE 3246, Ophthalmic Technologies VIII, (1 June 1998); doi: 10.1117/12.309418
Show Author Affiliations
Mitsumo Yamamichi, Bascom Palmer Eye Institute/Univ. of Miami School of Medicine and Fukuoka Univ. (United States)
Philippe Sourdille M.D., Clinique Sourdille (France)
Hassan Tahi, Bascom Palmer Eye Institute/Univ. of Miami School of Medicine and CHU Sart-Tilman/Univ. de (United States)
Valerie Jallet, Corneal SA (United States)
Franck L. Villain, Corneal SA and Univ. of Miami (France)
Francisco Fantes, Bascom Palmer Eye Institute/Univ. of Miami School of Medicine (United States)
Jean-Marie A. Parel, Univ. of Miami and Bascom Palmer Eye Institute/Univ. of Miami School of Medicine and Hotel (United States)

Published in SPIE Proceedings Vol. 3246:
Ophthalmic Technologies VIII
Pascal O. Rol; Karen Margaret Joos M.D.; Fabrice Manns, Editor(s)

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