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Proceedings Paper

Damage mechanisms of pico- and femtosecond laser retinal lesions as viewed by electron microscopy
Author(s): Cynthia A. Toth; Eric Kelvin Chiu; J. Michael Jumper; Benjamin A. Rockwell
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Paper Abstract

Retinal lesions produced by ultrashort laser pulses in the pico- and femtosecond range were examined by electron microscopy. Retinal pigment epithelial (RPE) cells that contained fractured and striated melanosomes typically exhibited severe damage to the other components of the cell. However, having observed RPE cell damage without coincident fractured melanosomes, it is thought that melanosome fracture itself is not responsible for the damage that occurs within the RPE cell. Nevertheless, the percentage of melanosomes fractured per lesion seems to parallel the severity of damage within that lesion site. No trend existed between percentage of melanosomes fractured and the peak power of laser delivery. However, with decreasing laser pulsewidth, there was a decrease in the percentage of melanosomes showing fracture.

Paper Details

Date Published: 18 May 1998
PDF: 5 pages
Proc. SPIE 3255, Applications of Ultrashort-Pulse Lasers in Medicine and Biology, (18 May 1998); doi: 10.1117/12.308216
Show Author Affiliations
Cynthia A. Toth, Duke Univ. Eye Ctr. (United States)
Eric Kelvin Chiu, Duke Univ. Eye Ctr. (United States)
J. Michael Jumper, Duke Univ. Eye Ctr. (United States)
Benjamin A. Rockwell, Air Force Research Lab. (United States)

Published in SPIE Proceedings Vol. 3255:
Applications of Ultrashort-Pulse Lasers in Medicine and Biology
Joseph Neev, Editor(s)

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