Share Email Print
cover

Proceedings Paper

Synthetic thrombus model for in-vitro studies of laser thrombolysis
Author(s): Robert E. Hermes; Keti Trajkovska
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

Laser thrombolysis is the controlled ablation of a thrombus (blood clot) blockage in a living arterial system. Theoretical modeling of the interaction of laser light with thrombi relies on the ability to perform in vitro experiments with well characterized surrogate materials. A synthetic thrombus formulation may offer more accurate results when compared to in vivo clinical experiments. We describe here the development of new surrogate materials based on formulations incorporating chicken egg, guar gum, modified food starch, and a laser light absorbing dye. The sound speed and physical consistency of the materials were very close to porcine (arterial) and human (venous) thrombi. Photographic and videotape recordings of pulsed dye laser ablation experiments under various experimental conditions were used to evaluate the new material as compared to in vitro tests with human (venous) thrombus. The characteristics of ablation and mass removal were similar to that of real thrombi, and therefore provide a more realistic model for in vitro laser thrombolysis when compared to gelatin.

Paper Details

Date Published: 13 May 1998
PDF: 7 pages
Proc. SPIE 3254, Laser-Tissue Interaction IX, (13 May 1998); doi: 10.1117/12.308166
Show Author Affiliations
Robert E. Hermes, Los Alamos National Lab. (United States)
Keti Trajkovska, Los Alamos National Lab. (United States)


Published in SPIE Proceedings Vol. 3254:
Laser-Tissue Interaction IX
Steven L. Jacques; Jeff Lotz, Editor(s)

© SPIE. Terms of Use
Back to Top