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Proceedings Paper

Laser-induced heat-diffusion-limited tissue coagulation: II. Effect of random temperature nonuniformities on the form of a spherical and cylindrical necrosis domain
Author(s): Igor A. Lubashevsky; Alexander V. Priezzhev
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Paper Abstract

When heated the living tissue exhibits temperature nonuniformities due to the vessel discreetness. On small scales the particular details of the vessel arraignments are practically unknown, so we regard such nonuniformities as random. When the tissue region affected directly by laser light is sufficiently small heat diffusion into the surrounding tissue is responsible for the necrosis growth. In this case strong temperature dependence of the thermal coagulation rate gives rise to the substantial perturbations the necrosis boundary due to the random temperature nonuniformities. In the previous papers we have analyzed this effect assuming the necrosis boundary quasiplane. In particular, we have found that for typical values of the tissue parameters the correlation length of such perturbations can be comparable with the necrosis size in magnitude. Therefore, the present paper studies the effect of the random temperature nonuniformities for a necrosis domain of spherical and cylindrical form. In this way we are able to analyze this effect for a more realistic situation, namely, depending on the form of an applicator delivering laser light inside the tissue. In particular, we have shown that for cylindrical applicators the effect of the vessel discreetness can be described by the developed previously model. For spherical applicators of small size (about several millimeters) this effect is depressed because in this case blood perfusion does not affect substantially the necrosis growth.

Paper Details

Date Published: 13 May 1998
PDF: 5 pages
Proc. SPIE 3254, Laser-Tissue Interaction IX, (13 May 1998); doi: 10.1117/12.308149
Show Author Affiliations
Igor A. Lubashevsky, Moscow State Univ. (Russia)
Alexander V. Priezzhev, Moscow State Univ. (Russia)

Published in SPIE Proceedings Vol. 3254:
Laser-Tissue Interaction IX
Steven L. Jacques; Jeff Lotz, Editor(s)

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