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Proceedings Paper

Development of a DNA biochip for gene diagnosis
Author(s): Tuan Vo-Dinh; Alan L. Wintenberg; M. Nance Ericson; Narayana R. Isola; Jean Pierre Alarie
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Paper Abstract

We describe a biochip based on an integrated circuit photodiode array for use in medical diagnostics. The biochip is a self-contained device which has photosensors, amplifiers, discriminators and logic circuitry on board. The development and evaluation of various microchip system components of the genosensor are discussed. The performance of the DNA biochip device is illustrated with fluorescence detection of DNA probes specific to gene fragments of the human immuno-deficiency virus 1 system. The usefulness and potential to the DNA biochip technology for rapid and cost- effective medical diagnostics is discussed.

Paper Details

Date Published: 1 May 1998
PDF: 7 pages
Proc. SPIE 3253, Biomedical Sensing and Imaging Technologies, (1 May 1998); doi: 10.1117/12.308046
Show Author Affiliations
Tuan Vo-Dinh, Oak Ridge National Lab. (United States)
Alan L. Wintenberg, Oak Ridge National Lab. (United States)
M. Nance Ericson, Oak Ridge National Lab. (United States)
Narayana R. Isola, Oak Ridge National Lab. (United States)
Jean Pierre Alarie, Oak Ridge National Lab. (United States)


Published in SPIE Proceedings Vol. 3253:
Biomedical Sensing and Imaging Technologies
Robert A. Lieberman; Tuan Vo-Dinh, Editor(s)

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