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Proceedings Paper

Application of a laser radar photogoniometer in the diagnosis of osteoporosis
Author(s): Hans-Georg Eberle; Juergen Beuthan; Marc Dierolf; Dieter Felsenberg; Wolfgang Gowin; Gerhard J. Mueller
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Paper Abstract

First results on angle dependent light scattering performed on normal and osteoporotic human bone tissue in vitro are presented. The scattering distributions are measured in cw mode as well as in time-resolved (time-gated) mode. Significant differences in the angular distribution of 675 nm laser radiation transmitted through normal or osteoporotic bones are found in cw-scattering measurements. For aspiring in situ results the transition in time-resolved measurements is needed to suppress the disturbing soft tissue signals. In this way, a characterization of the bone part is aimed by selectively recording the scattered signal in a suitable chosen time window. The measurement's principle is based on time-correlated single photon counting using a 10 ps laser diode (830 nm) and a micro channel plate- photomultiplier tube. First in vitro results on human lumbar vertebrae (L1) obtained with this equipment show a correlation between the thermal peak position and the FWHM of the scattered light pulses and the bone mineral densities determined by Dual X-ray absorptiometry. The angle dependent scattering curves give distinct indications on the bone status in transmission mode.

Paper Details

Date Published: 10 April 1998
PDF: 10 pages
Proc. SPIE 3259, Systems and Technologies for Clinical Diagnostics and Drug Discovery, (10 April 1998); doi: 10.1117/12.307321
Show Author Affiliations
Hans-Georg Eberle, Institut fuer Medizinische/Technische Physik und Lazermedizin/Freie Univ. Berlin (Germany)
Juergen Beuthan, Institut fuer Medizinizche/Technische und Lazermedizin/Freie Univ. Berlin (Germany)
Marc Dierolf, Laser- und Medizin-Technologie gGmbH (Germany)
Dieter Felsenberg, Universitatsklinikum Benjamin Franklin der Freien Univ. Berlin (Germany)
Wolfgang Gowin, Universitatsklinikum Benjamin Franklin der Freien Univ. Berlin (Germany)
Gerhard J. Mueller, Laser- und Medizin-Technologie gGmbH (Germany)

Published in SPIE Proceedings Vol. 3259:
Systems and Technologies for Clinical Diagnostics and Drug Discovery
Gerald E. Cohn; John C. Owicki, Editor(s)

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