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Proceedings Paper

Novel NIR instrument for noninvasive monitoring and quantification of cerebral tissue blood supply and oxygenation
Author(s): Zhixing Jiang; H. Sang Lee; David F. Wilson; Daniel F. Hanley
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Paper Abstract

We report the use of a pseudo-random modulated (PRM), low power laser diode based and dual wavelength NIR instrument for non-invasive, time-resolved spectroscopy (TRS) monitoring and quantification of the cerebral tissue blood supply and oxygenation. In vivo experiment have been conducted with dogs under hypoxia, hypercarbia and hemodilution conditions. Cerebral tissue blood supply and oxygenation are monitored through TRS of photon migration at wavelengths of 670 nm and 810 nm respectively. By (chi) 2 curve fitting the measured TRS with effective scattering and absorption coefficients as two variables, both effective scattering and absorption coefficients at each wavelength are extracted. It is found that under hypoxia condition, both scattering and absorption coefficients increases with the hypoxic level. This agrees with the physiology that the blood supply increase while the blood oxygenation decreases under hypoxia. Under hypercarbia condition, both scattering and absorption coefficients of 670 nm decreases with the increase of the hypercarbia level whereas those of 810 nm increases. These correspond to the increased blood supply and oxygenation. Under hemodilution condition, both scattering and absorption coefficients at both wavelengths decreases when the anemia level increases. Therefore, the cerebral tissue blood supply and oxygenation can be monitored and quantified in real-time and non-invasive manner.

Paper Details

Date Published: 24 April 1998
PDF: 7 pages
Proc. SPIE 3257, Infrared Spectroscopy: New Tool in Medicine, (24 April 1998); doi: 10.1117/12.306102
Show Author Affiliations
Zhixing Jiang, Science & Engineering Services Inc. (United States)
H. Sang Lee, Science & Engineering Services Inc. (United States)
David F. Wilson, The Johns Hopkins University (United States)
Daniel F. Hanley, The Johns Hopkins University (United States)


Published in SPIE Proceedings Vol. 3257:
Infrared Spectroscopy: New Tool in Medicine
Henry H. Mantsch; Michael Jackson, Editor(s)

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