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Proceedings Paper

Probing diseased skin with FT-Raman spectroscopy
Author(s): Elizabeth A. Carter; Adrian C. Williams; Brian W. Barry; Howell G.M. Edwards
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Paper Abstract

Healthy and abnormal human skin has been examined using Fourier transform (FT) Raman spectroscopy. The molecular basis of alternations in this tissue have been proved with the aim of providing a tool to aid in clinical diagnosis of skin disorders. Intact human stratum corneum show spectral features of keratin and the lipids. Spectra from callus and psoriatic tissue show that the keratin component is essentially intact and is similar to that in the normal tissue. However, the abnormal skin shows that the keratin component is essentially intact and is similar to that in the normal tissue. However, the abnormal skin shows a significant depletion of the lipoidal component, which correlates with clinical observations of an increase in permeability and the hyper-proliferative nature of these conditions. Verrucal tissue again shows some alterations to the lipoidal fraction of the tissue.

Paper Details

Date Published: 24 April 1998
PDF: 6 pages
Proc. SPIE 3257, Infrared Spectroscopy: New Tool in Medicine, (24 April 1998); doi: 10.1117/12.306085
Show Author Affiliations
Elizabeth A. Carter, Univ. of Bradford (United Kingdom)
Adrian C. Williams, Univ. of Bradford (United Kingdom)
Brian W. Barry, Univ. of Bradford (United Kingdom)
Howell G.M. Edwards, Univ. of Bradford (United Kingdom)


Published in SPIE Proceedings Vol. 3257:
Infrared Spectroscopy: New Tool in Medicine
Henry H. Mantsch; Michael Jackson, Editor(s)

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