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Proceedings Paper

Integrated endoscopic OCT system and in-vivo images of human internal organs
Author(s): Alexander M. Sergeev; Valentin M. Gelikonov; Grigory V. Gelikonov; Felix I. Feldchtein; Roman V. Kuranov; Natalia D. Gladkova; Natalia M. Shakhova; Ludmila Snopova; Andrei Shakhov; Irina N. Kuznetzova; Arkady Denisenko; Vitaly Pochinko; Yuri Chumakov; Valentin Almasov
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Paper Abstract

First results of endoscopic applications of optical coherence tomography (OCT) for in vivo studies of human mucosa in respiratory, gastrointestinal, urinary and genital tracts are presented. A novel endoscopic OCT (EOCT) system has been created that is based on the integration of a sampling arm of an all-optical-fiber interferometer into standard endoscopic devices using their biopsy channel to transmit low-coherence radiation to investigated tissue. We have studied mucous membranes of esophagus, larynx, stomach, urinary bladder, uterine cervix and endometrium as typical localization for carcinomatous processes. Images of tumor tissues versus healthy tissues have been recorded and analyzed. Violations of well-defined stratified healthy mucosa structure in cancered tissue is distinctly seen by EOCT, thus making this technique promising for early diagnosis of tumors and precise guiding of excisional biopsy.

Paper Details

Date Published: 24 April 1998
PDF: 11 pages
Proc. SPIE 3251, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications II, (24 April 1998); doi: 10.1117/12.306067
Show Author Affiliations
Alexander M. Sergeev, Institute of Applied Physics (Russia)
Valentin M. Gelikonov, Institute of Applied Physics (Russia)
Grigory V. Gelikonov, Institute of Applied Physics (Russia)
Felix I. Feldchtein, Institute of Applied Physics (United States)
Roman V. Kuranov, Institute of Applied Physics (Russia)
Natalia D. Gladkova, Institute of Applied Physics (Russia)
Natalia M. Shakhova, Nizhny Novgorod Medical Academy (Russia)
Ludmila Snopova, Nizhny Novgorod Medical Academy (Russia)
Andrei Shakhov, Nizhny Novgorod Medical Academy (Russia)
Irina N. Kuznetzova, Nizhny Novgorod Regional Hospital (Russia)
Arkady Denisenko, Nizhny Novgorod Regional Hospital (Russia)
Vitaly Pochinko, Nizhny Novgorod Regional Hospital (Russia)
Yuri Chumakov, Nizhny Novgorod Regional Hospital (Russia)
Valentin Almasov, Nizhny Novgorod Regional Diagnostic Ctr. (Russia)

Published in SPIE Proceedings Vol. 3251:
Coherence Domain Optical Methods in Biomedical Science and Clinical Applications II
Valery V. Tuchin; Joseph A. Izatt, Editor(s)

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