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Proceedings Paper

Autofluorescence of tissue surrounding malignant tumors
Author(s): Wolfgang Lohmann; Rainer M. Bohle; Wolf-Bernhard Schill; H. Vahrson; J. Mussmann
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Paper Abstract

In vitro fluorescence measurements on pap smears of ascites, pleura, or Douglas confirmed results obtained previously with different types of tissue: Cancer tissue fluoresces hardly and is surrounded by a 'fluorescence belt.' Investigations of cytological smears (e.g. Pap smears) have revealed the possible participation of granulocytes in this 'immune' reaction. Furthermore, there seems to be obvious differences in the fluorescence response of pap smears between ovarial- carcinomas and peritoneal carcinomas based on ovarial carcinoma. This observation cannot be explained yet. Because of its sensitivity and specificity the fluorescence method can be used as an additional tool for the evaluation of the tumor invasion front. Preferably it might be used for frozen sections of biopsies and surgical excisions.

Paper Details

Date Published: 24 April 1998
PDF: 7 pages
Proc. SPIE 3251, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications II, (24 April 1998); doi: 10.1117/12.306049
Show Author Affiliations
Wolfgang Lohmann, Univ. Giessen (Germany)
Rainer M. Bohle, Univ. Giessen (Germany)
Wolf-Bernhard Schill, Univ. Giessen (Germany)
H. Vahrson, Univ. Giessen (Germany)
J. Mussmann, Univ. Giessen (Germany)

Published in SPIE Proceedings Vol. 3251:
Coherence Domain Optical Methods in Biomedical Science and Clinical Applications II
Valery V. Tuchin; Joseph A. Izatt, Editor(s)

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