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Proceedings Paper

Time-resolved laser-induced fluorescence of lipids involved in development of atherosclerotic lesion lipid-rich core
Author(s): Laura Marcu; Jean-Michel I. Maarek; Warren S. Grundfest
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Paper Abstract

The goal of this study is to define the spectro-temporal fluorescence emission of the main types of lipoid that accumulate in atherosclerotic lesions cholesterol esters: cholesteryl linoleate (CL) and cholesteryl oleate (CO). CO is commonly found in fatty-streaks whereas CL and FC predominate in advanced lesions and their necrotic core. Fluorescence emission of the purified components was induced with Nitrogen laser pulses and detected with a MCP-PMT connected to a digital oscilloscope. Using a Laguerre expansion of kernels algorithm the intrinsic fluorescence pulses were deconvolved from the measured transient pulses. A double exponential function depicted the fluorescence decay characteristics.

Paper Details

Date Published: 16 April 1998
PDF: 10 pages
Proc. SPIE 3250, Optical Biopsy II, (16 April 1998); doi: 10.1117/12.305375
Show Author Affiliations
Laura Marcu, Univ. of Southern California and Cedars-Sinai Medical Ctr. (United States)
Jean-Michel I. Maarek, Univ. of Southern California (United States)
Warren S. Grundfest, Univ. of Southern California and Cedars-Sinai Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 3250:
Optical Biopsy II
Robert R. Alfano, Editor(s)

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