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Proceedings Paper

Raman detection of pigments in the human retina
Author(s): Werner Gellermann; Mihoko D. Yoshida; Robert W. McClane; Nikita Balashov; Paul S. Bernstein
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Paper Abstract

We have used resonance Raman scattering as a non-invasive optical technique to measure the concentration of carotenoid pigments in the human retina. The technique is highly sensitive and specific strength scales linearly with actual macular carotenoid content as measured by high-pressure liquid chromatography. This will facilitate studies of carotenoid distributions and their role in degenerative diseases of the eye and may allow for the rapid screening of carotenoid levels in large populations at risk for vision loss from age-related macular degeneration, the leading cause of blindness in the elderly in the US.

Paper Details

Date Published: 16 April 1998
PDF: 10 pages
Proc. SPIE 3250, Optical Biopsy II, (16 April 1998); doi: 10.1117/12.305368
Show Author Affiliations
Werner Gellermann, Univ. of Utah (United States)
Mihoko D. Yoshida, Univ. of Utah (United States)
Robert W. McClane, Univ. of Utah (United States)
Nikita Balashov, Univ. of Utah School of Medicine (United States)
Paul S. Bernstein, Univ. of Utah School of Medicine (United States)


Published in SPIE Proceedings Vol. 3250:
Optical Biopsy II
Robert R. Alfano, Editor(s)

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