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Proceedings Paper

Enhanced blood compatibility of silicon coated with a self-assembled poly(ethylene glycol) and monomethoxypoly(ethylene glycol)
Author(s): Miqin Zhang; Mauro Ferrari
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Paper Abstract

Silicon biomedical microdevices generally require surface modifications to improve their biocompatibility. ONe of the challenges in the field is the development of molecular coatings for devices with nanofeatures.In this paper we report the results of our investigation of synthetic poly(ethylene glycol) (PEG) and monomethoxypoly(ethylene glycol) (MPEG) coatings incorporating functional groups that in turn immobilize self-assembled monolayers. The properties of the modified surfaces were characterized by ellipsometry and scanning electron microscopy. Protein adsorption as well as platelet adhesion to the treated surfaces were studied to evaluate the non-fouling property of the PEG-enriched surface layers. Both PEG- and MPEG-modified surfaces showed significant suppression in plasma protein adsorption and platelet adhesion.

Paper Details

Date Published: 26 March 1998
PDF: 5 pages
Proc. SPIE 3258, Micro- and Nanofabricated Structures and Devices for Biomedical Environmental Applications, (26 March 1998); doi: 10.1117/12.304384
Show Author Affiliations
Miqin Zhang, Univ. of California/Berkeley (United States)
Mauro Ferrari, Univ. of California/Berkeley (United States)


Published in SPIE Proceedings Vol. 3258:
Micro- and Nanofabricated Structures and Devices for Biomedical Environmental Applications
Paul Lee Gourley, Editor(s)

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