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Proceedings Paper

Microfabricated devices for sizing DNA and sorting cells
Author(s): Hou-Pu Chou; Charles Spence; Axel Scherer; Stephen R. Quake
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Paper Abstract

We have microfabricated devices to size and sort microscopic biological objects, ranging from cells to single molecules of DNA. Sizing is accomplished by fluorescent excitation and detection. The devices are fabricated in a silicone elastomer using a replica method. Single molecules of DNA have been sized to 10 percent accuracy, and manipulation of E. Coli cells has been demonstrated.

Paper Details

Date Published: 26 March 1998
PDF: 7 pages
Proc. SPIE 3258, Micro- and Nanofabricated Structures and Devices for Biomedical Environmental Applications, (26 March 1998); doi: 10.1117/12.304378
Show Author Affiliations
Hou-Pu Chou, California Institute of Technology (United States)
Charles Spence, California Institute of Technology (United States)
Axel Scherer, California Institute of Technology (United States)
Stephen R. Quake, California Institute of Technology (United States)


Published in SPIE Proceedings Vol. 3258:
Micro- and Nanofabricated Structures and Devices for Biomedical Environmental Applications
Paul Lee Gourley, Editor(s)

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