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Proceedings Paper

Experimental study and first clinical results with a cooled applicator system for interstitial laser coagulation (LITT)
Author(s): Andre Roggan; Verena Knappe; Martin G. Mack; Thomas J. Vogl; Dirk Albrecht; Christoph-Thomas Germer; Joerg-Peter Ritz; F. Kniep; Gerhard J. Mueller
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Paper Abstract

Laser-induced interstitial thermotherapy has proven to be an effective method for the treatment of different types of tumors. Until now the attainable coagulation volume was limited by the maximum applicable energy. The limiting factor was the high tissue temperature around the applicator which may have caused applicator damage. Consequently an internally cooled catheter system has been developed in order to reduce the temperature of the applicator surface and to allow for the application of higher laser powers. The optimal treatment parameters for the Nd:YAG laser were determined on the basis of in vitro studies with porcine tissue. Following these experimental studies, 127 patients with liver metastases were treated with the cooled system. The applicator position and the resulting tissue damage were verified using a MRI on-line monitoring system applying a FLASH-2D sequence. The optimal in vivo treatment parameters were found to be 25 watts for an exposure time of 20 minutes, resulting in coagulated volumes of up to 20 cm3. The experimental and clinical results have proven that the combination of a scattering laser applicator with an internally flushed catheter enables a significant increase in the coagulation volume.

Paper Details

Date Published: 2 April 1998
PDF: 9 pages
Proc. SPIE 3249, Surgical Applications of Energy, (2 April 1998); doi: 10.1117/12.304354
Show Author Affiliations
Andre Roggan, Institut fuer Medizinsche/Technische Physik und Lasermedizin/Freie Univ. Berlin (Germany)
Verena Knappe, Laser- und Medizin-Technologie gGmbH (Germany)
Martin G. Mack, Universitatsklinikum Rudolf Virchow/Humboldt-Univ. zu Berlin (Germany)
Thomas J. Vogl, Universitatsklinikum Rudolf Virchow/Humboldt-Univ. zu Berlin (Germany)
Dirk Albrecht, Universitatsklinikum Benjamin Franklin der Freien Univ. Berlin (Germany)
Christoph-Thomas Germer, Universitatsklinikum Benjamin Franklin der Freien Univ. Berlin (Germany)
Joerg-Peter Ritz, Universitatsklinikum Benjamin Franklin der Freien Univ. Berlin (Germany)
F. Kniep, Somatex (Germany)
Gerhard J. Mueller, Institut fuer Medizinische/Technische Physik und Lasermedizin/freie Univ. Berlin and Laser (Germany)


Published in SPIE Proceedings Vol. 3249:
Surgical Applications of Energy
Thomas P. Ryan, Editor(s)

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