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Proceedings Paper

Electrical impedance imaging for tissue monitoring and assessment during thermal therapy
Author(s): Keith D. Paulsen; Alex Hartov; Kendra Sunshine Osterman; Rob Mazzarese; Todd E. Kerner
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Paper Abstract

Electrical properties of tissues in the 10 KHz to 10 MHz range are known to be temperature sensitive making the monitoring and assessment of thermal insult delivered for therapeutic purposes possible through imaging schemes which spatially resolve these changes. We have been developing electrical impedance imaging technology from both the hardware data acquisition and software image reconstruction perspectives in order to realize the capability of spectroscopically examining the electrical property response of tissues undergoing hyperthermia therapy. Results from simulations, in vitro phantom experiments and in vivo studies including in human patients are presented. Specifically, a new prototype multi-frequency data acquisition system which is functional to 1 MHz in both voltage and current modes is described. In addition, recent advances in image reconstruction methods which include the enhancement techniques of total variation minimization, dual meshing and spatial filtering are discussed. It is also clear that the electrical impedance spectrum of tissue has the potential to monitor other types of treatment-induced injury. Preliminary in vivo electrical impedance measurements in a rat leg model suggest that the tissue damage from radiation therapy can be tracked with this technique. Both dose and time-dependent responses have been observed in the electrical impedance data when compared to measurements recorded in an untreated control. Correlations with histological examination have also been performed and indicate that electrical impedance spectroscopy may provide unique information regarding tissue functional status and cellular morphology. Representative results from these studies are reported.

Paper Details

Date Published: 2 April 1998
PDF: 12 pages
Proc. SPIE 3249, Surgical Applications of Energy, (2 April 1998); doi: 10.1117/12.304343
Show Author Affiliations
Keith D. Paulsen, Dartmouth College and Norris Cotton Cancer Ctr. (United States)
Alex Hartov, Dartmouth College and Dartmouth Hitchcock Medical Ctr. (United States)
Kendra Sunshine Osterman, Dartmouth College (United States)
Rob Mazzarese, Dartmouth College (United States)
Todd E. Kerner, Dartmouth College and Dartmouth Hitchcock Medical Ctr. (United States)

Published in SPIE Proceedings Vol. 3249:
Surgical Applications of Energy
Thomas P. Ryan, Editor(s)

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