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Proceedings Paper

Preparation and characterization of Langmuir- and Langmuir-Blodgett layers of mixed skin lipids
Author(s): H. Schaffer; U. Bakowsky; T. Martini; Wolfgang Rettig; Horst Kresse
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Paper Abstract

The lipids of the stratum corneum fulfil a vital barrier function for the mammalian body. Cermides IV and cholesterol as the main components of stratum corneum as well as their mixtures have been investigated using Langmuir method at the air-water interface. Different 2D phases have been characterized by the aid of (Pi) /A isotherms and by fluorescence micrographs. The properties of films strongly depend on the composition of the mixtures. The Langmuir- Blodgett technique (LB) has been used for the preparation of supported monolayers. These LB layers have been investigated by atomic force microscopy and cyclic voltammetry. It could be shown that addition of small amounts of cholesterol to ceramides IV results in an improvement of the properties of the films: a decrease of electrical capacity of the layer and a decrease of the defect density of the film. In a film containing 50 mol percent ceramides IV an increase of the capacity and phase separation in the surface film has been observed.

Paper Details

Date Published: 1 January 1998
PDF: 4 pages
Proc. SPIE 3319, Liquid Crystals: Chemistry and Structure, (1 January 1998); doi: 10.1117/12.301317
Show Author Affiliations
H. Schaffer, Martin-Luther-Univ. Halle (Germany)
U. Bakowsky, Martin-Luther-Univ. Halle (Germany)
T. Martini, Max-Planck-Institut fuer Mikrostrukturphysik (Germany)
Wolfgang Rettig, Martin-Luther-Univ. Halle (Germany)
Horst Kresse, Martin-Luther-Univ. Halle (Germany)


Published in SPIE Proceedings Vol. 3319:
Liquid Crystals: Chemistry and Structure
Marzena Tykarska; Roman S. Dabrowski; Jerzy Zielinski, Editor(s)

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